Gene: SDHB ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1060503757
rs1060503757
SDHB
T 0.700 CausalMutation CLINVAR Cervical paragangliomas: is SDH genetic analysis systematically required? 17987308

2008
dbSNP: rs1060503757
rs1060503757
SDHB
T 0.700 CausalMutation CLINVAR Genetic testing in pheochromocytoma or functional paraganglioma. 16314641

2005
dbSNP: rs1060503757
rs1060503757
SDHB
T 0.700 CausalMutation CLINVAR The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas. 19454582

2009
dbSNP: rs1060503764
rs1060503764
SDHB
GA 0.700 CausalMutation CLINVAR Genetic testing in pheochromocytoma or functional paraganglioma. 16314641

2005
dbSNP: rs1060503764
rs1060503764
SDHB
GA 0.700 CausalMutation CLINVAR High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations. 17848412

2007
dbSNP: rs1060503764
rs1060503764
SDHB
GA 0.700 CausalMutation CLINVAR Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. 19351833

2009
dbSNP: rs1064794270
rs1064794270
SDHB
C 0.700 CausalMutation CLINVAR

dbSNP: rs1131691047
rs1131691047
SDHB
G 0.700 CausalMutation CLINVAR

dbSNP: rs1131691049
rs1131691049
SDHB
A 0.700 CausalMutation CLINVAR

dbSNP: rs1131691050
rs1131691050
SDHB
CTCCGT 0.700 CausalMutation CLINVAR

dbSNP: rs1131691053
rs1131691053
SDHB
GT 0.700 CausalMutation CLINVAR

dbSNP: rs1131691057
rs1131691057
SDHB
CT 0.700 CausalMutation CLINVAR

dbSNP: rs1131691059
rs1131691059
SDHB
CC 0.700 CausalMutation CLINVAR

dbSNP: rs1131691060
rs1131691060
SDHB
T 0.700 CausalMutation CLINVAR Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas. 12618761

2003
dbSNP: rs1131691061
rs1131691061
SDHB
T 0.700 CausalMutation CLINVAR Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis. 24096523

2014
dbSNP: rs1131691061
rs1131691061
SDHB
T 0.700 CausalMutation CLINVAR Head and neck paragangliomas: genetic spectrum and clinical variability in 79 consecutive patients. 22241717

2012
dbSNP: rs1131691061
rs1131691061
SDHB
T 0.700 CausalMutation CLINVAR Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. 19351833

2009
dbSNP: rs1131691061
rs1131691061
SDHB
T 0.700 CausalMutation CLINVAR Mutation screening in a Norwegian cohort with pheochromocytoma. 23407919

2013
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR Relevance of germline mutation screening in both familial and sporadic head and neck paraganglioma for early diagnosis and clinical management. 20208144

2010
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR Chromosomal changes in sporadic and familial head and neck paragangliomas. 19393419

2009
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes. 16317055

2006
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. 14500403

2003
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function. 22835832

2012
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. 16103922

2005
dbSNP: rs138996609
rs138996609
SDHB
A 0.700 CausalMutation CLINVAR Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. 19351833

2009